Joining the dots (or bars)

Joining the immunological dots in recurrent miscarriage.

While raised cellular immunity mediated by T helper (Th) 1 type cells may be harmful for the developing embryo/foetus, it is likely that Th2 type immunity may be helpful. The role of natural killer (NK) cells is presently underestimated, although they are clearly important in angiogenesis and the coordinated invasion of the decidua by the trophoblast. Deficient T regulatory cell (Treg) function...

Morphogenesis: Joining the Dots to Shape an Embryo

In the study of morphogenesis, how upstream signalling events are intricately linked to downstream cytoskeletal organisation is not entirely understood. Recent work in the Drosophila embryo has begun to shed light on this problem.

Antigenic Variation in Trypanosoma brucei: Joining the DOTs

Bulges or Bars from Secular Evolution?

We use high resolution collisionless N -body simulations to study the secular evolution of disk galaxies and in particular the final properties of disks that suffer a bar and perhaps a bar-buckling instability. Although we find that bars are not destroyed by the buckling instability, when we decompose the radial density profiles of the secularly-evolved disks into inner Sérsic and outer exponen...

Visual cortical neurons: are bars or gratings the optimal stimuli?

Neurons in the visual cortex of monkeys and cats have been characterized as either (i) bar and edge detectors or (ii) cells selective for certain spatial frequencies. To assess which of these functional descriptions is more accurate, we measured (i) the selectivity and (ii) the responsivity-sensitivity of these neurons to bars of various widths and gratings of various spatial frequencies. All o...